When were the four humors proved to be false?

Hi guys.


I'm doing a paper on Humorism in the midieval times. However, I cannot seem to find when it was, that the theory was proved not accurate.


Please help me out. :]


Also, if you find any other information regarding the four humors send me the site.When were the four humors proved to be false?
http://www.kheper.net/topics/typology/fo鈥?/a>